Abstract

NINA GARCIA, Nelson Miguel  and  HUARITA, Hernán. IDIOPATHIC THROMBOCYTOPENIC PURPURA IN ADULTS: EXPERIENCE FROM A TERTIARY CARE HOSPITAL, LA PAZ, BOLIVIA. Rev Cient Cienc Méd [online]. 2019, vol.22, n.2, pp.7-14. ISSN 2077-3323.

Introduction: Idiopathic thrombocytopenic purpura is an acquired disorder caused by autoantibodies against platelet antigens. To date have not been studied the clinical characteristics and treatment response in Bolivia. Objective: To describe the clinical characteristics and treatment outcomes in adult patients with newly diagnosed immune thrombocytopenic purpura. Methods: A descriptive, retrospective study of an adult case series with immune thrombocytopenic purpura was performed in a Hematology Service of La Paz, Bolivia during the period 2009-2014. Results: We included 23 patients with a median age of 59.9 years. All patients had hemorrhagic manifestations at diagnosis (nasal 82.6%, oral 56.5% and cutaneous 34.78%). The average platelet count was 26.7 x 109/L. The presence of antibodies against Helicobacter pylori was detected in 4 of 6 patients. The presence of normal or increased megakaryocyte numbers was the predominant finding in bone marrow. The response to first-line treatment was 96% (CR: 61%, R: 35%).After a mean follow-up of 24 months, 60% of the patients had a relapse in an average of 12.5 months from diagnosis. Conclusions: At the time of diagnosis, hemorrhagic manifestations are the most frequent, platelet counts are usually less than 30x109/L. Corticosteroids are the initial treatment of choice, with favorable responses in the majority of patients, however, more than half of the patients present relapse in an average time of 1 year.

Keywords : Idiopatic thrombocytopenic purpura; signs and symptoms; Bolivia; helicobacter pylori; thrombocytopenia.

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