SciELO - Scientific Electronic Library Online

 
vol.19 issue1RENAL ECOTOMOGRAPHY AS INITIAL STUDY IN HOSPITALIZED CHILDREN FOR PRESENTING URINARY TRACT INFECTION author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • Have no similar articlesSimilars in SciELO

Share


Revista Científica Ciencia Médica

Print version ISSN 2077-3323

Abstract

HERNANDEZ VILLARROEL, Luis Alfredo; CESIN, Luisa  and  FERNANDEZ, Henry. PENTOXIFYLLINE EFFECTS ON THE FORMATION OF POSTOPERATIVE PERITONEAL ADHESIONS IN RATS. Rev Cient Cienc Méd [online]. 2016, vol.19, n.1, pp.5-11. ISSN 2077-3323.

The Adhesions are a common and unfortunate consequence of most abdominal surgical operations. Some patients form extensive permanent adhesions that can cause abdominal or pelvic pain, infertility and bowel obstruction. Epidemiological studies have highlighted the extent of this problem and the cost to the health service, and although there are numerous approaches to prevent adhesions formation by decreasing peritoneal injury, the use of various adhesion barriers and topical pharmacological agents, no method so far has proved completely efficacious in randomized controlled trials. In this study, it decided to evaluate the effects of peritoneal exposure to Pentoxifylline in post-surgical adhesions in rats. Twenty female Sprague-Dawley rats underwent laparotomy. Postoperative peritoneal adhesions was induced by scarping serosal the surface of the colon. The animals were divided randomly into two experimental groups: a group treated with Pentoxifylline, and a control group. And were killed and evaluated at 15 postoperative days, decrease was observed in the number (p=0,025), severity (p=0,0018), extension (p=0,0013),density (p=0,0071), inflammation (p=0,0020), vascular proliferation (p=0,0007) and fibrosis score (p=0,0047) of adhesions in the group treated with Pentoxifylline, when compare to control group. In conclusion, this study demonstrated that the administration of Pentoxifylline intraperitoneally decrease significantly the peritoneal adhesions formation, and thus, may be useful for its prevention of same.

Keywords : Adhesions; surgery; pentoxifylline; rats.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License