SciELO - Scientific Electronic Library Online

 
vol.18 issue2Primary Serous Papillary Carcinoma: Case Report, Hospital Clinico Universidad de Chile 2010-2015Statistical analysis of patients from Cardiovascular Program in CESFAM Pinares, Chiguayante, Chile 2015 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • Have no similar articlesSimilars in SciELO

Share


Revista Científica Ciencia Médica

Print version ISSN 2077-3323

Abstract

FLEISCHMACHER ABRAHAMZ, Noelia  and  RIVERA, Helen. Expression of ki-67, p53, p16 and bcl-2 in Ameloblastomas. Rev Cient Cienc Méd [online]. 2015, vol.18, n.2, pp.18-23. ISSN 2077-3323.

The objective of this research was to determine the expression of Ki-67, p53, p16 and bcl-2 Solid and unicystic Ameloblastoma.This study was retrospective clinicopathological, experimental and correlational. Clinico-pathological analysis of the variables were: gender, age, anatomical site and histopathological diagnosis and immunohistochemical analysis using standardized protocol following the Ki-67, p16, p53 and bcl-2 markers in the Laboratory of Oral Histopathology "Dr. Pedro Tinoco "of the Faculty of Dentistry, Central University ofVenezuela during the period 2008-2013.The maxillofacial biopsies were sampled 34 cases diagnosed histopathologically as Ameloblastoma unicystic (16 cases), Ameloblastoma Solid (9 cases), and 9 cases as control diagnosis Odontogenic Tumor Queratoquístico statistical analysis for correlation of variables was performed through the Kruskal-Wallis test using SPSS statistical software version No. 20 MAC OSX system with a significance level of 99% (p <0.01).often males between the second and third decade of life was observed. Most frequent anatomical location in mandibular posterior, more frequent histopathological diagnosis unicystic ameloblastoma. Immunohistochemical analysis revealed the marcador Ki-67 as the expressed, followed by p53, bcl-2 and p16 indicating neoplastic transformation and proliferation associated with recurrence rate markers used are useful for assessing biological behavior to suggest appropriate surgical treatment in each case.

Keywords : Ameloblastoma; Immunohistochemistry; Prognosis.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License