Abstract

REBELLON SANCHEZ, David Esteban et al. Molecular changes involved in physiopathogeny of cancer and their utility for research in medicine. Rev Cient Cienc Méd [online]. 2014, vol.17, n.2, pp.44-52. ISSN 1817-7433.

Neoplasia, considered as a genetic disease that uses progression mechanisms similar to the normal tissues' when proliferates. Its presence is due to genetic alterations that facilitate tumor progression by failures in the mechanisms of cellular senescence and apoptosis. Within the main molecular alterations the most important are: aberrant expression of oncogenes, tumor suppressor genes, enzymes and transcription factors that promote abnormal cell cycle. The main objective of this paper is to review some of the molecular changes involved in the initiation, promotion and progression of neoplasms, in order to have genes useful information for earlier diagnosis of cancer, favoring the prognosis of genes disease, for diagnostic research in biotechnology and gene therapy.

Keywords : Cáncer; oncogenes; proto-oncogenes; tumor suppressor genes; carcinogenesis.

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