Introduction. -

The Osteoarthritis in the most common osteoarticularpathology in the world. Topical anti- inflammatory drugs are one of the main tools in its treatment, however, they lose their effectiveness over time or may present local adverse reactions, therefore, we have to look for other therapeutic options that are just as effective and safe.

Objectives. -

To evaluate the efficacy and safety of Baccharis latifolia 2% cream in the treatment of knee Osteoarthritis, comparing it with diclofenac 2% cream.

Material and methods. -

Clinical trials, comparative, double-blind study, carried out in adults with symptomatic knee osteoarthritis, dividing them into two groups in a randomized and blinded way for the participant and the treatingphysician, administering the herbal medicine to the first group and the second group topical anti-inflammatory, together with physiotherapy sessions, monitoring the response to pain treatment with VAS and WOMAC at the beginning and on the twelfth day of treatment.

Results. -

We obtained 100 patients of legal age, mostly female with a second degree of Osteoarthritis according to radiological images. We observed a decrease in pain, stiffness and improvement offunctionality statistically significant in both groups (p=<0.0001), no adverse reactions were observed in both groups.

Conclusions. -

The efficacy and safety of Baccharis latifolia 2% cream was similar to diclofenac 2% gel, this being a possible alternative in patients who lose effectiveness or have adverse reactions to standard treatment.

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