Abstract

GUACHALLA CASTRO, Carlos  and  QUISPE RODRIGUEZ, Mónica. PRIMARY IGG SUBCLASS-3 DEFICIENCY ASSOCIATED WITH GRANULOMATOSIS WITH POLYANGEITIS, RELATING TO A CASE. Rev. Méd. La Paz [online]. 2024, vol.30, n.2, pp.48-51.  Epub Sep 30, 2024. ISSN 1726-8958.

Vasculitic diseases are frequently complicated by lung infections, as in the present clinical case where we treated a patient with granulomatosis with polyangiitis, with a clinical picture of pneumonia that is difficult to treat due to lack of response to broad- spectrum antibacterial therapy. This leads us to reconsider differential diagnoses, emphasizing that the underlying cause is another associated disease, such as a primary or secondary immunodeficiency that is more prevalent in adulthood. Doing a thorough clinical analysis we came to the conclusion of a primary deficiency of IgG subclass-3. The patient received immunoglobulin replacement therapy with clinical improvement.

Keywords : IgG subclass-3 deficiency; vasculitis; immunodeficiency.

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