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Revista Médica La Paz

versão On-line ISSN 1726-8958

Resumo

JIMENEZ, Gabriela et al. NEURAL TUBE DEFECTS IN NEWBORNS AT “HOSPITAL DE LA MUJER”. Rev. Méd. La Paz [online]. 2023, vol.29, n.2, pp.11-20.  Epub 30-Dez-2023. ISSN 1726-8958.

OBJECTIVE:

To know the prevalence at birth of neural tube defects in newborns at Hospital de La Mujer, La Paz, Bolivia, 3650 m.a.s.l, period between 2008 - 2017.

PLACE:

Women’s Hospital, La Paz, Bolivia.

METHODS:

Observational, descriptive, cross-sectional, retrospective. The clinical records of all newborns were examined, in an already established period. For the detection of congenital anomalies, birth registration books were used. The data were entered into an Excel database, and analyzed through the use of descriptive statistics.

RESULTS:

58120 newborn records were examined, 1269 cases with Congenital Anomalies (2.2%) with a prevalence at Birth (PB) of 21.83/10.000 RN (22.57/10.000 RN alive) were presented. Of these 1269 cases, 69 (5,44%) corresponded to Neural Tube Defects (NTD), with a PB of 11.87/10,000 RN (12.27/10,000 RN alive), 59.42% DTN associated with the male sex. The most frequent type of NTD evidenced was Myelomeningocele (52.17%), and stillborn DTNs represented 17.39%.

CONCLUSIONS:

The distinctive difference found (predilection of NTD for the male sex), could suggest the presence of a quantitatively greater genetic load (typical of the population studied) in the etiology of NTDs in our environment, since when multifactorial conditions affect the less frequently described sex, a greater weight of genetic factors can be assumed compared to environmental factors, following concepts of heritability and the threshold theory for this mode of inheritance; however, we are aware that a larger sample size is needed to arrive at more accurate conclusions, these factors are added to the underreporting and possible recording biases evidenced during the study.

Palavras-chave : Neural Tube Defects; Congenital Anomalies; La Paz.

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