Abstract

URQUIZO AYALA, Guillermo; ARCE CHUQUIMIA, Jackeline  and  ALANOCA MAMANI, Gladys. BACTERIAL RESISTANCE BY EXTENDED SPECTRUM BETA LACTAMASE: A GROWING PROBLEM. Rev. Méd. La Paz [online]. 2018, vol.24, n.2, pp.77-83. ISSN 1726-8958.

The beta-lactamase (ESBL) spread spectrum are enzymes that generate most of the b-lactamic resistance, including penicillin, cephalosporins of first, second, third generation, monobactams, except the cephamycin and carbapenem. This resistance was increased by the indiscriminate use of cephalosporins to even mild infections. Also, frequently have other genes for antimicrobials such as aminoglycosides, tetracycline and co-trimoxazole. In addition, ESBL (+) strains are most frequently resistant to quinolones to non-ESBL producing strains. The current resistance that exists to the extended-spectrum beta lactamase increase mortality rates, in patients with infections begin empirical treatments, which do not have good clinical response to evolve reaches sepsis. The treatment of choice in these cases is the use of carbapenem, recommendation based mainly that relies mainly on the result of resistance observed in vitro. The new carbapenem, ertapenem or doripenem appear to have an excellent activity. He is a review of the basics of the appearance of ESBL and its importance in the management of patients with infectious pictures, which are frequent presentation in referral Hospitals.

Keywords : b - lactamases; ESBL strains; bacterial resistance.

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