Abstract

VERA CARRASCO, Oscar. Characterization of the etiological, physiopathological, clinical and therapeutic aspects of sepsis and septic shock. Cuad. - Hosp. Clín. [online]. 2023, vol.64, n.2, pp.66-77. ISSN 1562-6776.

Abstract Sepsis is a clinical syndrome based on a complex and dynamic interaction between pathogen and host. The identification of different phenotypes and the heterogeneity of sepsis requires a paradigm shift in its diagnosis and treatment. Septic shock is defined as a sepsis­induced hypotension that persists despite adequate fluid resuscitation, accompanied by perfusion abnormalities or organ dysfunction. It may also involve the need for vasopressor drugs to correct blood pressure. It is a type of distributive shock, characterized by reduced systemic vascular resistance and typically increased cardiac output. In recent years, the management of sepsis has evolved with a special focus on septic shock (SS) due to its severity and higher morbidity and mortality. Considering the above, this review aims to characterize this condition in terms ofits etiological, pathophysiological, clinical, and therapeutic aspects

Keywords : sepsis; septic shock; etiology; pathophysiology; clinical presentation; treatment.

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