Resumo

URQUIETA-MALDONADO, Miguel A; LEON-ROMERO, Juan J; HINOJOSA-CARVAJAL, Sergio  e  RODRIGUEZ-CAMARA, Favio. Serum álbumin predicator of intrahospital outcomes in patients admitted to the NICU of the Women's Hospital. Cuad. - Hosp. Clín. [online]. 2023, vol.64, n.1, pp.41-51. ISSN 1562-6776.

Abstract Introduction: In metabolic stress, there is a protein overproduction of "positive acute phase reactants" and in the liver, the synthesis of other proteins, including albumin, called "negative acute phase reactants" is slowed down. Precise reference ranges for pathologic hypoalbuminemia have proven difficult to determine in neonates. Material and methods: Descriptive cross section in 494 newborns. An exploratory analysis of the data with descriptive statistics was carried out using the statistical package SPSS v.20. Results: 494 neonates were selected, 39% were late preterm, 27% reported hypoalbuminemia in its different degrees that correlated with the days of hospitalization in the NI CU (p=0.0001), need and time on a mechanical ventilator (p=0.001), with mortality (p=0.001) and infectious pathology (p=0.001). Discussion: The cumulative incidence of sepsis not confirmed by blood culture was 54%. Hypoalbuminemia has important associations with outcome and prognosis in pediatric patients. CRP does not correlate the study (p=0.232) and was only reactive in 4 patients (0.8%). Conclusions: Serum albumin level reported in the first 24 hours of NICU admission is a predictor for in-hospital outcomes (time and requirement of mechanical ventilation), neonatal mortality, neonatal sepsis, and hyaline membrane disease. Its serum determination should be included in the list of laboratory tests requested upon admission and the PCR upon admission should be excluded due to its poor sensitivity, as suggested by SIBEN

Palavras-chave : Serum albumin; mortality; sepsis; neonates; NICU.

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