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Cuadernos Hospital de Clínicas

Print version ISSN 1562-6776

Abstract

SAN MIGUEL-SIMBRON, José L; MUNOZ-VERA, Maruska  and  URTEAGA-MAMANI, Noelia A. Quality of measurementin scientific research in a high-altitude context: at the atomic level interlaboratory study analysis, Deuterium Oxide by FTIR - 2021. Cuad. - Hosp. Clín. [online]. 2022, vol.63, n.2, pp.94-102. ISSN 1562-6776.

Abstract Concepts of knowing how to do scientific research associated with the quality of measurements are presented, and within it on the intrinsic quality of the measurement of variables, aimed at two conditions of the same: precision and accuracy. Forms of precision evaluation are described, such as the coefficient of variation and the technical error of the measurements. On the other hand, forms of accuracy evaluation are described, such as linear regression and Z-score. Actions and tools to improve both precision and accuracy are also suggested and described. The analysis of water enriched with deuterium oxide is a topic that was taken into account by the International Atomic Energy Agency (IAEA), Vienna, Austria, in the 2021 management, and an activity was organized through the "Interlaboratory Study, Deuterium Oxide by FTIR - 2021". The purpose was to ensure comprehensive quality in the capacity built in the use of stable isotope techniques for the evaluation of health and nutritional status. Likewise, to evaluate the quality of measurement of the relative accuracy of the enrichment of water with deuterium oxide in 43 laboratories at the international level, a group that included the Atomic Biology Laboratory (LABA) of the Growth and Development Unit (UCREDE). Linear regression and Z-score were used to assess accuracy. It is concluded that the results demonstrated a very good performance in relative accuracy with the FTIR equipment that measured deuterium enrichment in water samples

Keywords : Body composition; precision and accuracy; stable isotopes; high altitude.

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