Abstract

CHAVEZ-RAMOS, M A et al. SubGroups A₁,A₂ and A_INT in effective donors of the maternal and child blood bank CNS La Paz - Bolivia. Cuad. - Hosp. Clín. [online]. 2020, vol.61, n.2, pp.17-22. ISSN 1562-6776.

Abstract In addition to the ABO system, its subgroups review great importance in Immunohematology. Subgroups A differ both in the number of antigenic sites and in the configuration of the erythrocyte antigen. The main ones, A1 and A2 differ in that A1 erythrocytes are agglutinated by human Anti-A1 antibody or by Anti-A 1 Lectin (Dolichos biflorus), and A2 erythrocytes are agglutinated by Anti-H Lectin (Ulex europaeus). Materials and methods: A descriptive, cross-sectional study was conducted. The physical and electronic records of the Blood Bank were analyzed, all effective donors were included, which were typified by the Immunohematology Laboratory in the period of May. to July 2018. Method used, agglutination in tube and in microplate. Results: In a total of 1599 protocols, it was determined that group O has the highest frequency with 84% and the least frequent was the AB with 0.66%. According to blood group A and AB we have the following frequencies: A1 representing (73.3%), A2 (15.9%), Aint (5.65%), A1B (3.60%) and A2B (1.55%). The clinical importance is based on the fact that some people in group A2 transfused with A1, can produce Anti-A1 which is an irregular natural antibody active at 22 ° C but sometimes it is active at 37 ° C causing an extravascular transfusión reaction, so if A2 erythrocytes are not available, it is recommended to transfuse group O erythrocytes.

Keywords : Immunohematology; antibodies; subgroups; Lectin.

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