Abstract

GIUSEPPE-LIISTRO  and  AJATA-CHURA, A. FEV1/FEV6 and FEV6 an alternative for FEV1/FVC and FVC in the detection of airway obstruction. Cuad. - Hosp. Clín. [online]. 2020, vol.61, n.1, pp.52-59. ISSN 1562-6776.

Abstract Introduction: The aim of this study was to verify if fixed cut-off points and lower limit of normal (LLN) for forced expiratory volume in one second (FEV1)/FEV6 and FEV6 as an alternative for FEV1/forced vital capacity (FVC) and FVC are valid for the detection of obstructive lung disease in a sample of Bolivian subjects. Methods: A total of 92 spirometric consecutive tests from subjects, 66 males and 26 females at risk for COPD were analyzed. The study population included residents of city Santa Cruz de la Sierra, (Bolivia) aged from 35 to 90 yrs., from various ethnical origins (cosmopolitan city). Results: Sensibility and specificity were 97.0 % and 96.9 %, respectively when fixed cut-off valúes of FEV1/FEV6 of 0.73 was compared to FEV1/FVC<0.7 as standard, according to GOLD recommendations to detect airway obstruction. Sensibility and specificity were 100 % and 89.5 %, respectively when LLN of FEV1/FVC and FEV1/FEV6 were used. Conclusions: In conclusión, FEV6 is a valid surrogate for FVC to detect airway obstruction, either using fixed cut-off points or LLN. Further study is needed to verify these results in a larger population and to establish local spirometric predicted valúes.

Keywords : COPD; spirometry; FEV1/FVC; FEV1/FVC; FEV6; asthma; airway obstruction.

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