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Gaceta Médica Boliviana

Print version ISSN 1012-2966On-line version ISSN 2227-3662


SALLAMA CHOQUE, Mildred; RIVERA GUZMAN, María Roxana  and  HERBAS COSTAS, María Shirley. Haptoglobin genotyping as a cardiovascular risk factor in diabetic patients at Hospital Clínico Viedma. Gac Med Bol [online]. 2023, vol.46, n.2, pp.81-86.  Epub Dec 01, 2023. ISSN 1012-2966.


in patients with diabetes mellitus, the haptoglobin genotype is considered a risk factor for the onset of heart disease. It has been reported that in diabetics, the Hp 2-2 genotype generates a five-fold greater risk of developing cardiovascular disease compared to diabetic patients with another genotype. This study aims to determine the haptoglobin genotype in diabetic patients who come to the Viedma Clinical Hospital laboratory from November 2018 to January 2019.


76 sera from fasting diabetic patients with a lipid profile request were analyzed. For the determination of the three haptoglobin genotypes, a commercial enzyme immunoassay kit (Hp-Epitope ELISA) was used; The enzymatic method was used to determine glycemia and lipid profile.


of the total studied population of diabetic patients, 12% have the Hp 2-2 genotype. In those uncontrolled patients, the glycemia values (201 mg/dl) are statistically significant in relation to the other two genotypes. These uncontrolled diabetic patients with the Hp 2-2 genotype also have significantly elevated levels of cholesterol, LDL, VLDL and triglycerides in relation to the other two genotypes.


our results coincide with previous studies which indicate that diabetic patients who have the Hp 2-2 genotype have a greater risk of suffering from cardiovascular disease compared to the other 2 genotypes.

Keywords : diabetes mellitus; cardiovascular diseases; blood Glucose; hemoglobins; hyperlipidemias.

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