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Gaceta Médica Boliviana
Print version ISSN 1012-2966On-line version ISSN 2227-3662
Abstract
GETAZ, Laurent and CASTRO SOTO, Maria del Rosario. Sensitivity of the ELISA test for the detection of IgG antibodies against Strongyloides stercoralis among immunocompromised patients. Gac Med Bol [online]. 2023, vol.46, n.1, pp.14-17. Epub June 01, 2023. ISSN 1012-2966. https://doi.org/10.47993/gmb.v46i1.613.
Objectives:
the sensitivity of coproparasitological tests for the diagnosis of strongyloidiasis are suboptimal. Serological methods are more sensitive, but studies among immunocompromised patients are scarce. The aim of this study was to evaluate the sensitivity of a commercial ELISA test among immunocompromised patients.
Methods:
a multicenter study was conducted in Bolivia among patients with cancer, HIV, rheumatologic or hematologic diseases. 88 patients with S. stercoralis larvae in stool identified by coproparasitological techniques had an ELISA serological test (Bordier Affinity Products). Results: the sensitivity of the ELISA technique was 77,3% (61/88) (CI95%: 67,7-85,1), and was identified lower among HIV+ patients with CD4<300 (64,5%) than among HIV+ patients with CD4>300 or unknown HIV serology (84,2%) (p=0,035).
Conclusions:
the sensitivity of ELISA is inversely proportional to the degree of immunosuppression. This result reinforces the recommendation to diagnose strongyloidiasis by a combination of serological and coproparasitological techniques.
Keywords : Strongyloides stercoralis; serologic tests; parasitic sensitivity tests; enzyme-linked immunosorbent assay.
