Objective:

to evaluate the analgesic and gastroprotective activity of extracts and infusion of muña (Minthostachys mollis) and llantén (Plantago major) leaves, using biological tests in Rattus norvegicus.

Methods:

an experimental, prospective, longitudinal study was conducted in which the analgesic and gastroprotective activity was evaluated in 30 Rattus norvegicus divided into six lots: control, standard, problem I, II, III, IV, to which abdominal convulsions were induced with glacial acetic acid and gastric ulcers with absolute ethanol.

Results:

the infusion of muña and llantén presented 81.4% analgesic activity and an effectiveness percentage above 100%, 60% gastroprotective activity and 100% effectiveness in relation to the number of lesions. Similarly, 69.6% gastroprotective activity and 95.9% effectiveness with respect to the degree of injury. These percentages described were higher in comparison to the percentages of muña extract, llantén extract, combined extracts. The ANOVA one-factor Kruskal-Wallis test revealed a statistically significant difference (p<0.05 (p=0.013 number of convulsions); 95% CI) in analgesic activity and a non-significant difference in gastroprotective activity (p>0.05 (p=0.167 number of lesions and p=0.384 degree of injury); 95% CI).

Conclusions:

the infusion of muña and llantén has better analgesic and gastroprotective activity compared to the extracts.

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