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Gaceta Médica Boliviana

Print version ISSN 1012-2966On-line version ISSN 2227-3662

Abstract

OMONTE RODRIGUEZ, Liz Adriana  and  BUSTAMANTE GARCIA, Zulema. Antioxidant, antibacterial and cytostatic activity of extracts of Turmeric (Curcuma longa). Gac Med Bol [online]. 2022, vol.45, n.1, pp.12-16. ISSN 1012-2966.  https://doi.org/10.47993/gmb.v45i1.323.

Part of the pharmaceutical industry is developed on the basis of new plants discovered by indigenous peoples, turmeric, used in a traditional way for the treatment of skin, liver, digestive, carcinogenic, parasitic, viral, bacterial infections, among others.

Objective:

to evaluate the antioxidant, antibacterial, toxic and cytostatic activity and to determine the phytochemistry of the turmeric (Curcuma longa) extract, grown in the Cristal Mayu area of Chapare.

Methods:

two ethanolic extracts 70% and 96% were prepared, polyphenols were quantified by Folin-ciocalteu method, antioxidant activity was evaluated with DPPH reagent, antibacterial activity was evaluated with two gram negative bacteria (E. coli and K. pneumoniae) and one gram positive bacteria (S. aureus), toxicity on Artemia salina and cytostatic activity was determined by lettuce root growth inhibition assay. Total curcuminoids were quantified.

Results:

the 96% extract has a higher amount of total phenols and antioxidant activity. Only the 96% extract showed antibacterial activity against S. aureus, E. coli, K. pneumopniae. On the other hand, turmeric has toxicity against Artemia salina, inhibits the growth of lettuce root and has 5% of total curcuminoids.

Conclusions:

characterization of the compounds confirms their composition as polyphenols, which relates to their biological activity, showing that Turmeric has antioxidant, antibacterial and cytotoxic activity, as well as its importance in the healthcare field as an alternative treatment for various diseases.

Keywords : artemia; cytotoxicity; turmeric; curcuminoids; phytochemicals; metabolite.

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