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Gaceta Médica Boliviana

Print version ISSN 1012-2966On-line version ISSN 2227-3662


ROJAS CABRERA, Ernesto et al. Intralesional Application of Antimonials in the Treatment of Cutaneous Leishmaniasis. Gac Med Bol [online]. 2022, vol.45, n.1, pp.6-11. ISSN 1012-2966.


to evaluate the clinical efficacy of intralesional application of 3 versus 6 injections of Glucantime® for one or two weeks in patients with cutaneous leishmaniasis.


quasi-experimental study. 41 patients with cutaneous leishmaniasis were included from the tropical endemic area of Cochabamba, Bolivia. Participants were randomly assigned to receive intralesional treatment with Glucantime®, in three or six applications. All patients signed a written consent to voluntarily participate in the study, approved by the ethics committee of the UMSS medical school.


evaluation of the clinical effectiveness of three or six intralesional applications of Glucantime® found no statistically significant differences between the two. Likewise, no significance differences were found regarding complete healing achieved at one month post-treatment by both application schemes.


ulcer healing observed in this study was achieved independent of the scheme of either three or six intralesional applications of Glucantime® and these results are comparable to systemic treatment. Three intralesional Glucantime® applications are considered to be the minimal treatment limit for cutaneous leishmaniasis with a single ulcer smaller than three by three centimeters.

Keywords : drug administration schedule; intralesional injections; cutaneous leishmaniasis.

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