Abstract

VALLEJOS ROCABADO, Ana Mabel; GARRON TORRICO, M. Placida  and  BACARREZA GARCIA, Jhonny Eduardo. Overlap Syndrome (Autoimmune Hepatitis- Primary Biliary Cholangitis) in Patient with Cryoglobulinemia. Gac Med Bol [online]. 2021, vol.44, n.2, pp.268-270. ISSN 1012-2966.  https://doi.org/10.47993/gmb.v44i2.359.

A 55-year-old female patient with a history of mixed cryoglobulinemia with renal involvement, membranoproliferative glomerulonephritis, chronic kidney disease (CKD) stage G5, presented with jaundice, choluria, complementary examinations showed increased liver tests with hypertransaminasemia, hyperbilirubinemia and cholestasis, negative viral liver serologies, anti-mitochondrial antibody (AMA) +, a liver biopsy was performed identifying interphase hepatitis and in the interior of the fibrous septa, focal ductal reaction and slight proliferation of branches of the portal vein which are distorted between thick collagen fibres, leading to the diagnosis of overlap syndrome, treatment was started with corticosteroids 1 mg/Kg/day and ursodeoxycholic acid 13 mg/kg/day with good evolution, achieving normalization of liver enzymes. Both pathologies “mixed cryoglobulinemia and autoimmune hepatopathies” are rare entities that respond well to immunosuppressive and immunomodulatory treatment.

Keywords : autoimmunity; cholangitis; cholestasis; hepatitis; liver; kidney diseases.

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