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Gaceta Médica Boliviana

versión impresa ISSN 1012-2966versión On-line ISSN 2227-3662


MORENO, Javier Mauricio  y  BURBANO, Adriana. Quinolone use as a Risk Factor for Severe Opportunistic Candida Infection in Critically Ill Adult Patients. Gac Med Bol [online]. 2021, vol.44, n.2, pp.225-232. ISSN 1012-2966.


Candida is one of the microorganisms most frequently isolated from positive blood cultures, showing an increase in its prevalence worldwide due to multiple risk factors, one of the most important being the use of extended-spectrum antibiotic therapy, such as quinolones used in critical patients in intensive care wards, of which the literature is tangential in its relationship with the development of invasive candidiasis,


a search of biomedical databases MEDLINE, PubMed, ScienceDirect, Scopus, Embase, was performed using the search strategy: "Candidemia AND Quinolones AND Adult" other strategies were also used to increase sensitivity such as: "Invasive candidiasis AND Quinolones" and "Candidemia OR Invasive candidiasis AND risk factors" including English, Spanish, French and Portuguese languages, articles type were taken into account: [Randomized Controlled Trial], [Clinical Trial], [Controlled Clinical Trial] and [Review].


The biomedical literature is scarce regarding the description of the relationship between the use of quinolones as a risk factor for developing invasive candidiasis; however, eight studies were found with important statistical significance that show a close relationship between the proposed phenomenon.


Systemic quinolones such as Ciprofloxacin are a confirmed risk factor associated with invasive fungal infections such as Candida.

Palabras clave : Invasive candidiasis; Quinolones; Intensive Care; Adults; Risk Factors; Drug Resistance.

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