Abstract

MEDRANO, Viviana et al. Immune System, SARS-CoV-2 Infection and Development of COVID-19. Gac Med Bol [online]. 2021, vol.44, n.2, pp.214-218. ISSN 1012-2966.  https://doi.org/10.47993/gmb.v44i2.296.

The SARS-CoV-2 infection promotes a lack of control of the immune system with a predominance of a rapidly onset inflammatory response and the triggering of a cytokine storm. The objective of this review is to understand better the immune mechanisms and their lack of control activated by SARS-CoV-2. The activation of innate immunity against infection is the key factor for viral control or its progression towards COVID-19. The adaptive immune response is also disturbed by SARS-CoV-2, which enables a higher infection rate, as well as systemic immune lack of control that can trigger shock and tissue damage in different organs, death from COVID-19 or autoimmunity post-COVID-19.

Keywords : COVID-19; uncontrolled immunity; cytokine storm.

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