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Gaceta Médica Boliviana

Print version ISSN 1012-2966On-line version ISSN 2227-3662


BEJARANO GONZALES, Lisset et al. Multidrug-resistant Acinetobacter Baumannii and its Relationship with Biofilm Production. Gac Med Bol [online]. 2021, vol.44, n.2, pp.148-153. ISSN 1012-2966.


Acinetobacter baumannii is the Gram-negative bacterium associated with hospital infections due to its great ease of survival in adverse conditions and the development of multi-resistance to various antimicrobials. For years, hospital outbreaks have been registered in different countries associated with this bacterium, which increased the interest in studying biofilms and the genes involved in their production, since an association with antibiotic resistance was demonstrated.


To establish a relationship between multiresistance to different antibiotics and biofilm formation in Acinetobacter baumannii isolates.


acinetobacter baumannii strains were studied using real-time polymerase chain reaction (PCR) for the detection of bap, csuE, ompA, oxa-51 genes from 191 samples, in addition to the quantification of the biofilm formed following the technique described by Badmasti and Azizi.


this study was carried out on 191 Acinetobacter baumannii strains from two hospital centers for the identification of genes associated with biofilms and subsequent quantification according to the technique described by Badmasti and Azizi. Demonstrating an association between biofilms and Acinetobacter baumannii bacterial resistance.


the results demonstrated a positive association between the amount of biofilm formed and antibiotic resistance. Strong biofilm-forming bacteria show greater resistance to carbapenems. Regarding the genes, the ompA gene showed an association with the amount of biofilm produced, bap and csuE are genes involved in the first step of biofilm formation, but they are not associated with the amount formed by the bacteria

Keywords : Acinetobacter baumannii; carbapenems; drug resistance; microbial; disease outbreaks; biofilms.

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