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Gaceta Médica Boliviana

On-line version ISSN 1012-2966


ROJAS CABRERA, Ernesto; VERDUGUEZ-ORELLANA, Aleida; CORDOVA ROJAS, Marisol  and  GUZMAN-RIVERO, Miguel. Perilesional meglumine antimonate in cutaneous leishmaniasis with systemic therapeutic failure: series of cases. Gac Med Bol [online]. 2019, vol.42, n.1, pp.74-78. ISSN 1012-2966.

In Bolivia, the drugs used for the treatment of cutaneous leishmaniasis are the antimonials by systemic application in doses / kg/weight, which cause adverse effects due to the applications in long periods and large volumes. The perilesional application of antimony has similar therapeutic efficacy than the systemic one. However, there is no documented information regarding the efficacy of perilesional treatment in patients with therapeutic failure after systemic treatment. The aim of this series of cases was to evaluate the perilesional treatment with Glucantime®, in patients with cutaneous leishmaniasis and therapeutic failure, after a first cycle of systemic treatment with antimonials. The study was conducted with eleven patients with cutaneous leishmaniasis and therapeutic failure, after the administration of a first cycle of systemic treatment with Glucantime®. from the tropical zone of Bolivia. The persistence of the lesion and the presence of parasites at the edge of the lesion were considered as therapeutic failure. The perilesional intervention consisted in the application past one day of glucantime® in five sessions. The inoculation was performed on the edge of the lesion and the dosage of the medication was calculated by multiplying the area of the lesion by the factor 0.008. All the cases presented local pain during the time of inoculation of the drug, as well as a slight enlargement of the area of the lesion after the first inoculation of the drug. In the following inoculations the progressive reduction of the area of the lesion was observed until its complete healing.

Keywords : cutaneous leishmaniasis; therapeutic failure; perilesional treatment; adverse effects.

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