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Gaceta Médica Boliviana

On-line version ISSN 1012-2966


TORREZ MORALES, Froilán  and  MORALES CESPEDES, Lizeth Sandra. Procalcitonin, as subclinic predictor of corioamnionitis . Gac Med Bol [online]. 2019, vol.42, n.1, pp.29-31. ISSN 1012-2966.

Objectives: to determine the importance of serum procalcitonin as a subclinical predictor of chorioamnionitis in patients with premature rupture of membranes at the German Urquidi Maternal and Child Hospital. Methods: in the absence of studies on serum procalcitonin in the early diagnosis of subclinical chorioamnionitis, this study is framed in a quasi-experimental and prospective approach; We included 85 patients from a population of 280 who were admitted with a diagnosis of Premature Membrane Rupture from 28 to 32 weeks of gestation in the German Urquidi Maternal and Child Hospital, from April 2017 to February 2018. A documented review, form validation, data collection, determination of serial serum procalcitonin was performed, using the Gibss criteria as a contrast test, proceeding with data analysis, conclusions and recommendations. Results: between day 2 to 8 of RPM, an average of 10.53% of the studied population, not having clinical data of chorioamnionitis, showed results of serum procalcitonin greater than 0.5 ng / ml, considering itself positive suggestive of infection. It was evidenced, significant statistical differences with a gradual increase of the clinical indicators mainly on days 5 and 8 in 10.5% and 16.4% respectively; making reference that procalcitonin seems to be a competent early marker of infection. It was possible to establish for serum procalcitonin in the diagnosis of subclinical chorioamnionitis, a sensitivity of 72%, a specificity of 66.6%, a positive predictive value of 62%, a negative predictive value of 36.9%, when applied between days 2 to 8 of RPM. Conclusions: procalcitonin serum should be taken into account as a diagnostic alternative of subclinical chorioamnionitis to take timely behaviors.

Keywords : chorioamnionitis; procalcitonin; intramniotic infection; subclinical diagnosis.

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