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Gaceta Médica Boliviana

On-line version ISSN 1012-2966


ALEGRE ANDRADE, Patricia. Efficacy of ondansetron in prevention of maternal hypotension after spinal anesthesia. Gac Med Bol [online]. 2018, vol.41, n.1, pp.41-46. ISSN 1012-2966.

Maternal hypotension is a common complication of spinal anesthesia during cesarean section. Blocking serotonin 5-HT receptors could reduce the incidence of hypotension and the use of vasopressors. Objetive: efficacy of ondansetron as prevention of maternal hypotension after spinal anesthesia. Methods: a total of 72 patients randomized, clinic ensay and single-blind. Ondansetron was administered 5 minutes before the spinal anesthetic. Group O4 (4 mg), group O8 (8 mg) and group P (placeb) in a 10 ml syringe were measured heart rate, blood pressure mean, dermatome level reached, Apgar scores and maternal complications. Results: there was significant difference between the groups in terms of the incidence of hypotension and it was observed that the vasopressor requirement was lower in group O8 (p = 0,000), maternal adverse events (p = 0.087) were lower when ondansetron is applied. APGAR scores were similar in the groups (p = 0, 373). Conclusion: use of ondansetron is determined to attenuate the incidence of hypotension although the exact dose in obstetric patients is not clear, it is also clear that it also decreases the vasopressor requirement, adverse effects such as pruritus, nausea and vomiting. Limitations number of study patients and gasometric analysis due to lack of input in the hospital.

Keywords : ondansetron; hypotension; elective cesarean; norepinephrine; spinal anesthesia.

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