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Gaceta Médica Boliviana

versión On-line ISSN 1012-2966


CAMACHO CRUZ, Marilyn; GARCIA SAINZ, Mario; GARCIA MOREIRA, Gloria Beatriz  y  CAMACHO CRUZ, Lizbeth. Vaginal progesterone combined with nifedipine in The prevention of pretermine labor with short cervix. Gac Med Bol [online]. 2017, vol.40, n.2, pp. 08-11. ISSN 1012-2966.

Objective: evaluate the effects of Vaginal Progesterone combined with nifedipine compared to the single use of nifedipine in the threat of preterm delivery in pregnant women between 24-34 weeks with cervical length ≤ 25mm in the Hospital Materno Infantil Germán Urquidi. Method: a prospective, comparative and analytical cohort study was conducted. It is a design of two groups (comparative) where the selection of patients was made according to inclusion and exclusion criteria, we evaluated 231 patients. Results: the time to exceed the Preterm Childbirth episode, 67% of the patients who used progesterone plus nifedipine resolved the event within the first hour compared to 50% of patients who used only nifedipine. With the combination of progesterone and nifedipine, the episode of Premature Birth Threat between 24 and 34 weeks of gestation was controlled within 1 hour, with the sole use of nifedipine, from 32-34 weeks there is an average of 2 hours in excess of episode. With only nifedipine as tocolytic, 80% of the patients verified delivery at 5 days. Only 20% were able to exceed 10 days of latency. The combination progesterone + nifedipine achieved that 30% of the patients reached a latency between 21-30 days, Gestational age at birth with the combination progesterone + nifedipino reaches 80% an age less than or equal to 37 weeks 6 days. Conclusions: the combination of vaginal progesterone plus nifedipine substantially improves the neonatal prognosis in all the results obtained, the use of nifedipine alone has less beneficial effects in this investigation.

Palabras clave : nifedipine; vaginal progesterone; tocolysis; preterm delivery; threat.

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