Abstract

MEDINA BUSTOS, Marcos; UGARTE CUBA, Tayita; GOMEZ PAZ, Ximena  and  CONDORI A., Ivonne.   Direct serological detection of congenital hypothyroidism vs. filter paper method. Gac Med Bol [online]. 2015, vol.38, n.1, pp.10-13. ISSN 1012-2966.

Objectives: to demonstrate the usefulness of direct serological method for direct detection of congenital hypothyroidism. Methods: a cross-sectional comparative study; for comparing the diagnostic performance of the technique of filter paper with the direct serological detection of neonatal TSH in the same group of infants examined. The study included 202 healthy newborns Hospital Materno Infantil Cochabamba, between 48 hrs. and 21 days of life; in the first quarter of 2014. The statistical analysis was performed comparing the curves of sensitivity and specificity with the Receiver Operating Characteristic (Receiver Operating Characteristic), specialized MedCalc statistical package, version 12.7. The descriptive analysis was performed using SPSS-IBM STADISTIC, version 19. Results: both techniques showed high sensitivity and specificity, with an area under the curve both close to 0.972 (ROC) IC 0.941 to 0.989, 95 %. Conclusions: both techniques proved effective in the diagnostic screening for congenital hypothyroidism.

Keywords : congenital hypothyroidism; chemiluminescence; inmunofluorometría.

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