Abstract

FLORES LEON¹, Amilcar; CORDOVA ROJAS, N. Marisol; MAMANI HERRER, Karina  and  EGUEZ SUAREZ, Emilse. Role of anti-Toxoplasma gondii antibodies in immune responses in pregnant women.. Gac Med Bol [online]. 2013, vol.36, n.2, pp.76-80. ISSN 1012-2966.

Objectives: the study aimed to evaluate in vitro the role of anti T. gondiiin activating immune responses in pregnant women. Methods: the study was performed with peripheral blood mononuclear cells (PBMC) of pregnant women with chronic toxoplasmosis (n = 15) were stimulated in the presence and absence of autologous plasma (PA) (anti T. gondii antibody). Results: the data show that in PBMC stimu-lated in the absence of autologous plasma there is increased cell proliferation (P < 0.05) than cells in the presence of autologous plasma. Levels of IFN- y produced in both conditions (PA and SBF) were similar. Comparing the production of IFN- y vs IL - 10 shows increased production of Th1 cytokines. Conclusions: in general, our results suggest that the antibodies present in autologous plasma modulate the immune response in pregnant women with chronic toxoplasmosis, such that the immune system does not exacerbate or inhibit this specific response. The presence of antibodies to T. gondii not affecting IFN- y production in pregnant women with chronic toxoplasmosis, but if cell proliferation.

Keywords : Chronic Toxoplasmosis in pregnant women; anti-Toxoplasma gondii antibodies; cytokines; cell proliferation.

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