Abstract

MOSTAJO-RADJI, Mohammed A.  and  M.R. FERREIRA, Leonardo. Changlng cell identity to create true personalized medicine. Gac Med Bol [online]. 2012, vol.35, n.2, pp.76-79. ISSN 1012-2966.

The 2012 Nobel Prize in Physiology or Medicine was awarded to Sir John Gurdon and Shinya Yamanaka for their breakthroughs in cellular reprogramming. These discoveries not only changed our view of the process of cell fate determination, but also hold the potential to revolutionize medicine. By providing a brief historical context and a succinct summary of the current methodologies, we present the major advances in basic research, as well as their potential applications to the clinic. This review aims to provide a concise overview of the current state of the field and its implications for therapy.

Keywords : cellular reprogramming; stem cells; pluripotency; personalized medicine.