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vol.35 issue1Effect of supplementation of megadoses of Vitamin A in children severely malnourished and healthy children, Cochabamba, Bolivia author indexsubject indexarticles search
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Gaceta Médica Boliviana

Print version ISSN 1012-2966On-line version ISSN 2227-3662


ZALLES CUETO, Lourdes; PAZ SOLDAN, Ricardo Sevilla  and  GAMARRA SALAS, María Luisa. Usefulness of Inflammatory Prognostic Index and Nutrition (PINI) in the diagnosis of children with severe malnutrition. Gac Med Bol [online]. 2012, vol.35, n.1, pp.7-11. ISSN 1012-2966.

Objectives: To evaluate the prognostic inflammatory and nutritional index (PINI) by determining Albumin, Prealbumin, Alpha-1-glyco-protein and C-reactive protein as a predictor of risk for nutritional rehabilitation of severely malnourished children. Methods: We studied 36 children (as) in hospitalized malnourished CRIN infected and 30 children (as) controls between 6 months and 5 years with anthropo-metric and nutritional assessment. Hematological parameters were determined, and nutritional and inflammatory proteins by turbidi-metry. The results were expressed as mean ± standard deviation with ANOVA one-way and Student's t test. 95% statistical confidence (P <0.05) with the statistical package STATA. 10. Results: Anthropometry showed a significant difference in all parameters compared with the control group and reference threshold of the National Center for Health Statistics. Hematologic parameters below the lower limit of normality. 69% with anemia, 19 were deficient transferrin, leukocytosis 25%, 8% eosinophilia, 14% neutrophils and 14% parasitized. The albumin and prealbumin concentrations significantly decreased, the Alpha-1-acid glycoprotein and C-reactive protein significantly hig-her than control children (p<0.001). 25% showed a weak risk PINI, 42% moderate risk, high risk 22% and 11% correlated with life-threa-tening comorbidities. Healthy children, a PINI less than 1. Conclusions: The PINI as a complement to the clinic helps to assess the initial severity of the infection, to foresee and monitor trends in child malnutrition. A micromethod is simple, fast as it can be repeated regularly.

Keywords : predict of risk; malnutrition; inflammation.

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