Resumo

SEVILLA PAZ SOLDAN, Ricardo et al. Effect of Lactobacillus rhamnosus GG in immune-nutritional recovery of severely malnourished children. Gac Med Bol [online]. 2011, vol.34, n.2, pp.71-75. ISSN 1012-2966.

Objectives: to assess the effect of Lactobacillus rhamnosus GG in the recovery of cell mediated immune and nutritional satatus of severely malnourished children. Methods: experimental, randomized, double-blind, controlled in severely malnourished children admitted to the CRIN of the Children's Hospital Manuel Ascencio Villarroel in Cochabamba, Bolivia. Entered thestudy with theconsentof parents, 44 children with severe malnutrition according to inclusion and exclusion criteria, (21 children study group: 23 children control group). Assessedbyanthropometry, psychomotordevelopment, immune response, lymphocytecounting subpopulationsCD3,CD1a, CD71 and ultrasonography of the thymus and monitoring with CLAPSEN strategy.The study group received Lactobacillus rhamnosus GG 108/g day in a range of three days and standardized diet with micronutrients. The control group received the same diet and placebo. Data were analyzed with SPSS 19. Results: children in the study group improved P/TZ = 0.71 ± 0.99 SD (p <0.001) IC:95%(1.7- 045), the control group P /TZ =-1.83 ± 1.15 DE, PBZ,T/ EZ, PCZ with no significant difference. The development of fine motor area: 69.00 ± 15.31 vs. control group: 60.39 ± 14.50 (p < 0.06) IC:95% (0.46-17.68).There was a lower incidence of infections, no significant difference; the recovery time wasreduced to 24.28 ± 2.1 days (P ≤ 0.001) vs. 33.17 ± 2.80 days of the control group. It was verified Reductionof immature lymphocyte populations with better distribution and greater surface area of thymus 489.61 ± 163.68 vs.. 372.85 ± 84.12 in the control group. Conclusions: Lactobacillus rhamnosus GG, improve and shorten nutritional recovery time and cell-mediate response.

Palavras-chave : malnutrition; probiotics; nutritional recovery.

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