Abstract

KOLLER, James; JENSEN, Mauricio  and  GUERRER, M. Lourdes. Endoscopic-Hystopathological Correlation of Helicobacter Pylory Cag-A. Gac Med Bol [online]. 2009, vol.32, n.1, pp.13-15. ISSN 1012-2966.

Abstract Currently more of half people of the world is infected with Helicobacter Pilory but only from 10 to 20 % develops the di-sease, the variation in the clinical result of the pathology induced by the Helicobacter Pilory is multifactorial, one of these factors is the virulence factor, having been identified the genotypes, cagA, vacA and ice A. that contribuys in the pa-thogeny. The genotype cagA has been associated with peptic ulcer, atrophy of the mucous gastric and gastric cáncer, identified as a factor of virulence of H. pylori and the causer for these complications in many world series. The aim of our work was to determinet the genotype cagA of helicobacter in our enviroment, by means of ELISA and to see his correlation with the finds endoscopios and histopatologics of the gastric mucous in patients of the Bolivian Japa-nese Institute of Gastroenterology of cochabamba. They were included in the study 171 positive patients to H. pylori, diagnosed by any ofthree used methods: rapid Test of Ureasa, Serology and Histology, in these patients by means serology with ELISA there were detected positivity To cagA in 101 (59.1 % ) ofthe patients with 66.3 % ofthe females and 33.7 % males of 39.5 % years, with a range from 29 to 59years. The wart gastritis, nodular gastritis, erosive gastritis and the sore duodenal were the finds endoscopios more frequent in the patients with H.pylori cagA (+). In the patients with diagnosis histopatologic of metaplasia intestinal and gastric atrophy, not find statistically significant difference between the patients cagA positives vs the negatives, but ¡fin those with chronic active gastritis (67.7 % ) h. Pylori cagA positive.

Keywords : Helicobacter pylory cagA; Endoscopio; chronic active Gastritis.

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