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Gaceta Médica Boliviana

versión On-line ISSN 1012-2966


SEVILLA, Ricardo et al. Inmunodepression and inmunorestauration on chidren with serious proteic energetic desnutrition. Gac Med Bol [online]. 2009, vol.32, n.1, pp. 5-12. ISSN 1012-2966.

It's known that the inmune system of malnouruished children has a worst performance , and it can be reverted with an improved diet. About 1500 severe malnourished children, 211 were selected to form study groups and control in 5 different treatment schemes. Prior parental consent, were randomized, controlled, according to inclusión criteria: severe malnourished, without infection, using techniques previously validated. Were monitored: growth, infections, immune response (lymphocyte subpopulations count / ultrasound th ym us). Th e y received a supply of calories, protein, vitam ins: fat soluble and water soluble. Group I (LPG ) has received initial diet low in lactose. Group II (G Z ) Zincsupplementation. Group III (G M A), megadoses of vitamin A + Z n . Group IV (Z n F e) received zinc, ¡ron and vitam in A. Group V: (G VM ) received a diet rich in arginine, lysine, leucine, isoleucine and valine, plus all the nutrients tested in other groups. Group I, improved nutrient raw milk and vegetable oil supply, correcting the calories, fat soluble vitamins and essential fatty acids. In Group II improved the immune response, growth and control of diseases added. Group II I (GM A) decreased the prevalence of infections. Th e G IV (Z n F e ) synergistically optimize immune recovery and levéis of hemoglobin. Group V (GM V) showed better recovery of the thym us and lymphocyte populations in relation to the other groups. The study showed that sequential immunosuppression of malnourished children can be overeóme with a properdiet rich in nutrients and am ino acid immunostimulants.

Palabras clave : Nutrients; inmunodepression; inmunorestsauration Children.

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