Gaceta Médica Boliviana
Print version ISSN 1012-2966
ARMAZA CESPEDES, Ada Ximena and CAMPUZANO JIMENEZ, Sandra Marlene. METAANÁLISIS: SEGURIDAD DE LA ADMINISTRACIÓN DE QUINOLONAS PARA EL TRATAMIENTO DE INFECCIONES EN LA POBLACIÓN PEDIATRICA. Gac Med Bol [online]. 2006, vol.29, n.1, pp. 56-62. ISSN 1012-2966.
The quinolonas are antimicrobials of wide spectrum, its administration has been associated with adverse articular effects in young animals. Caution is recommended in the quinolonas use in pediatrics, restricting its use for situations where another alternative doesn't exist. To evaluate the security of the quinolonas administration for treatment of infections in the pediatric age, we present an metaanalysis of randomized and controlled trials (RCT), during the period of 1995-2005. Electronic databases of bibliographical references as The Index Medicus and Excerpta, MEDLINE and EMBASE respectively, through controlled language, controlled search, using the Thesaurus, electronic indicator, as dictionary of the database, Cochrane Library, search free, more controlled search using the constrainers, had been used. All the randomized controlled trial were included, they compare the treatment with quinolonas in front of a control in pediatric patient. Seven RCT were included that used quinolonas in children and adolescents in the intervention group and in a control group an antibiotic of another family, about the adverse articular effects. The metaanalysis demonstrated that the risk of inducing effects adverse in articulations is similar in the two groups. In the carried out metaanalysis it is verified that there is not significant increment of the risk (RR) of affectation to articulate with the quinolonas use to established dose.
Keywords : Quinolonas; metaanalysis; MEDLINE; Cochrane Library; Randomized Controlled Trials (RCT).