Resumen

ZALLES CUETO, Lourdes; CONDARCO, María del Carmen  y  DAVILA ORELLANA, Rufo. RECEPTOR DE TRANSFERRINA (CD71) COMO INDICADOR PARA EL DIAGNOSTICO DE ANEMIA FERROPENICA: ESTUDIO COMPARATIVO. Gac Med Bol [online]. 2005, vol.28, n.2, pp.9-16. ISSN 1012-2966.

The diagnosis of anaemia due to iron deficiency classically is made when the séric ferritin is diminished or when the iron administration induces an increase of serie haemoglobin. This deficiency is associated with increase of transferrine receptors expression at eritroid or lymphocyte immature cells surface that respond to the demand of intracellular iron by increase of receptors turnover. Our objective was to study the sensitivity and specifícity of the transferrina receptors (CD71) present in T lymphocytes, in contrast to traditional indicators used to diagnose ferropénic anemia. One thousand of scholar children of both sexes were studied, whose ages were between 6to 10 years oíd registered in periurbans public schools of Cochabamba. The study group was conformed by 101 anaemically children and 35 healthy children. The following biochemical parameters were determined: hemoglobina, hematocrito, séric iron, ferritine, transferrine and transferrine receptors (CD71). The analysis of our results revealed that the transferrine receptors CD71, are the only indicators that precisely discriminate between anaemic children due to iron deficiency and healthy children. The hemoglobine has similar behaviour because it was used as cut point to select the studied group. Unlike the traditional indicators, the transferrine and CD71 receptors respectively displayed a specifícity of 100% and sensitivity of 88% and 99%, which means 100% of probability for the diagnosis of anaemic children, being the CD71 the most sensible and specific indicator to appreciate physiological iron reserves and to demónstrate a deficiency associated to the deficiency of it.

Palabras clave : Transferrine receptor, CD71; T limphocyte; ferropenic anaemia.

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