SciELO - Scientific Electronic Library Online

 
vol.35 issue1Critical reviews on stability and Photosensitizer potential of metal ferrocyanides: a possible prebiotic mineral; part (II)Use of bacteria obtained from whey and its potential use as probiotics in the food industry. A short review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista Boliviana de Química

On-line version ISSN 0250-5460

Abstract

AFIEROHO, Ozadheoghene E et al. An antiplasmodial depside from a nigerian lichen dirinaria picta, epiphytic on the oil palm Elaeis Guineense. Rev. Bol. Quim [online]. 2018, vol.35, n.1, pp.31-39. ISSN 0250-5460.

This study investigated the anti-plasmodial and cytotoxic potentials of the chloroform (LCE) and ethanol (LEE) extracts from the foliose lichen Dirinaria picta with the view of isolating anti-malarial drug lead compound(s). In vitro anti-plasmodial and cytotoxicity assays were done using the plasmodium lactate dehydrogenase assay and human HeLa cervica cell lines respectively. The structure of the isolated compound was elucidated using spectroscopic techniques. The LCE yielded a novel antiplasmodial depside 1 (antiplasmodial IC50≈37 (μg/mL; cytotoxicity (IC50 >100 μg/mL; Selectivity index >2.7) and an impure fraction LC2 (antiplasmodial IC50 ≈ 79 μg/mL; cytotoxicity (IC50 >100 μg/mL; Selectivity index <1.3). The LEE (antiplasmodial IC50 ≈ 17 μg/mL; cytotoxicity (IC50 ≈ 62 μg/mL; Selectivity index ≈ 3.7) showed a significantly (p < 0.05) better anti-plasmodial activity though more cytotoxic compared to depside 1 and LC2.The depside 1, LC2 and LEE were less cytotoxic compared to emetine (cytotoxicity (IC50 = 0.02 μM ≈ 0.013 μg/mL) though not as active as the reference drugs chloroquine (antiplasmodial IC50 = 0.031 μM 0.016 μg/mL). This is the first time report on the anti-malarial potential of Nigerian lichens and the isolation of a novel anti-plasmodial depside 1.

Keywords : Lichens; Depside; Anti-plasmodial; Cytotoxicity; Drug discovery.

        · abstract in Spanish     · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License