Resumo

LOZANO, Maribel; FLORES, Yonny R.  e  ALMANZA, Giovanna R.. HIGH CONTENTS OF OLEANOLIC ACID IN HIGHLAND BOLIVIAN PLANTS . Rev. Bol. Quim [online]. 2017, vol.34, n.1, pp.28-32. ISSN 0250-5460.

ABSTRACT Oleanolic acid is a pentacyclic triterpenoid widely distributed in the plant kingdom, it has several pharmacological properties and it has been marketed in China as hepatoprotective drug since decades. The plants are the main source of this interesting compound, in this sense; during this study we quantified this metabolite in several Bolivian highland plants (Tetraglochin cristatum, Lampaya castellani, Junellia seriphioides, Baccharis tola, Polylepis tomentella, P. hieronyni, P. besseri and Satureja boliviana) by a high-performance liquid chromatography (HPLC) method. The amount determined (2,87 to 22,69 mg/g) was higher than the concentration reported for the olive fruit (0,17-0,56 mg/g) and similar than the reported for olive leaf (31,0 mg/g) which is the main source of commercial oleanolic acid. So native species, such as Junellia seriphioides (22,69 mg/g), Lampaya castellani (13,87 mg/g), Baccharis tola (11,93 mg/g) and Polylepis besseri bark (11,06 mg/g) are an interesting potential natural source of oleanolic acid in the región.

Palavras-chave : Oleanolic acid; HPLC quantification; Bolivian highland plants; Junellia seriphioides; Lampaya castellani; Baccharis tola; Polylepis besseri.