Abstract

P., Blas et al. Synthesis of the anti-cancer carboplatin oxidized, and study of its interactions with n-bases by cyclic voltammetry. Rev. Bol. Quim [online]. 2015, vol.32, n.3, pp.53-59. ISSN 0250-5460.

The anticancer drug cis-diammine-(1,1-cyclobutanedicarboxylate)-trans-dihydroxyplatinum (IV) or carboplatin-oxidized was synthesized with 98% purity by oxidizing the carboplatin Pt (II) with hydrogen peroxide 30%. The elemental analysis was confirmed by Atlantic Microlab Inc. Company (Norcross-Georgia, USA). The study of the electrochemical behavior of CBDCAOX interacting with nitrogenous bases was performed in a range of -200 mV to -700 mV with a voltammetric analyzer BAS 50W model. The free CBDCAOX voltammogram showed a reduction signal in -625.4 mV and during the interaction with thymine the signal shifted to less negative potentials. This result indicates the formation of a strong bond in CBDCAOX-thymine complex. Spanish title: Síntesis del anticanceroso carboplatino oxidado y estudios electroquímicos de sus interacciones con bases nitrogenadas por voltametría cíclica.

Keywords : Oxidized-carboplatin; Nitrogenous bases; Gold electrode; Potentials; Adducts.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )