Abstract

PUMA-CAPARO, Blas P.  and  VEGA-OLIVENCIA, Carmen A.. Electrochemical behaviour of anti-cancer drug carboplatin and interactions with nitrogenous bases on gold electrode. Rev. Bol. Quim [online]. 2015, vol.32, n.2, pp.30-36. ISSN 0250-5460.

The electrochemical behavior results of anticancer Carboplatin (CBDCA) and interactions with adenine, guanine, cytosine and thymine (BASES), allowed knowing the formation of strong bonds between CBDCA, adenine and guanine. These bonds stop DNA replication in cancer cells. The study was carried out by cyclic voltammetry BAS 50W model on a gold electrode at pH = 7,4 and Proton Nuclear Magnetic Resonance ¹H-NMR. The Free CBDCA voltammogram showed an oxidation signal on + 685,5 mV and CBDCA-BASES adducts showed a displacement and disappearance of the CBDCA oxidation signal.

Keywords : Carboplatin; Nitrogenous bases; Gold electrode; Adducts.

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