Abstract

NEGRON ARROYO, Claudia C et al. PLASMA ANTIOXIDANT CAPACITYIN HIGHLAND SUBJECTS EXPOSED AT 5200 METERS OF ALTITUDE. Rev. Bol. Quim [online]. 2014, vol.31, n.1, pp.1-4. ISSN 0250-5460.

ABSTRACT Human exposure to high altitude conditions (reduced barometric pressure) leads to the formation of free radicals, which could be a major cause of altitude sickness. In the present study the total antioxidant capacity (TAC) was measured by two methods, FRAP (ferric reducing antioxidant power) and ABTS (2,2 '-azino-bis-3-6-sulfonic acid ethylbenzotiazolin acid) in the blood plasma samples of 15 non-smoking Bolivians (10 men and 5 women), who were exposed to large changes in altitude from 3,600 to 5,200 meters. The average antioxidant activity for ABTS at 3600 m was 560 umol Trolox Equivalent./l of plasma and for FRAP 569 umol Trolox Equivalent./l of plasma... After exposure to 5200 m, the ABTS and FRAP showed an increment in average of 602 umol Trolox Equivalent./l of plasma and 642 umol Trolox Equivalent./l of plasma. Both methods showed a high linear correlation for all samples. After exposure of subjects to extreme altitude, the results showed a significant increase in the level of antioxidants in blood plasma samples especially for the FRAP method

Keywords : antioxidant capacity; blood; high altitude sickness.

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