Abstract

BASCOPE, Marcelo; VILA, Jose; EROSA, Gilda  and  STERNERª, Olov. DNA AFFINITY SCREENING OF PLANTS FROM THE BOLIVIAN AMAZONAS RAIN FOREST. Rev. Bol. Quim [online]. 2010, vol.27, n.2, pp.100-103. ISSN 0250-5460.

Six crude extracts of plants from the Bolivian Amazonas rainforest were subject of DNA affinity screening, to identify potential antitumor and antimalarial activity, the assay uses a HPLC method, based on the ability of antitumor agents to reduce DNA peak size. Three extracts showed positive peak reduction, two were negative and resulted inconclusive, further observations indicate that the presence of the DNA in the mixture also reduces or eliminates substances peaks in the Chromatogram, possibly indicating specific affinity

Keywords : Crude extracts; DNA affinity; antitumor; antimalarial; HPLC; Bolivian Amazonas.

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