Abstract

NAVARRO G., Elvira et al. VALORACIÓN DE LA TOXICIDAD AGUDA IN VIVO DEL ÁCIDO ÚSNICO. Rev. Bol. Quim [online]. 2010, vol.27, n.2, pp.89-93. ISSN 0250-5460.

An experimental study was realized, the main objective was evaluated, toxic effect of usnic acid, isolated from a lichen usnea spp.  determination of lethal dose at 50% mortality (dl₅₀) throughout reed muench mathematical method  and the probit graphical method. The selected animals were albino female swiss mice, weighted between 18 and 20g,  using a 2000 mg/kg, 1000 mg/kg, 775 mg/kg, 662 mg/kg, 550 mg/kg and 175 mg/kg by kilogram corporal weight, as dose administrated by orogastric via under study during 14 days. The result comes out a dl₅₀ between 798.47 mg/kg and 776.25 mg/kg. according to the williams criteria, usnic acid is considered a lightly toxic product. The methodology and the experimental designed was carried out following the described orientation by the epa (ambient protection agency) 870.1100, oecd 425 (economic organization for trade and development), that covers the 24 most develop nations of the world, for the application of the acute toxicity class method (cta).      Corresponding author: juan_antonio_avila@hotmail.com

Keywords : Toxicidad aguda; DL₅₀; Usnea spp; ácido úsnico.

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