Abstract

VALDIVIA, Ana C et al. Activation of the free fatty acid receptor GPR40 by (+)-curcuphenol and related synthetic compounds. Rev. Bol. Quim [online]. 2009, vol.26, n.2, pp.77-82. ISSN 0250-5460.

The bio-guided fractionation of an ethanol extract of Baccharis genistelloides (L) Baker, a plant that traditionally is used to treat diabetes, yielded (+)-curcuphenol (1) as agonist of GPR40, a cell surface receptor for free fatty acids. This paper describes the agonistic activity of 1 as well as of a series of semi-synthetic and synthetic analogues

Keywords : GPR40; Baccharis genistelloides; (+)-Curcuphenol; (+)-Curcuphenol-methyl-ether; (+)-Dihydrocurcuphenol; 1-Bisabolone; 1-Bisabolol; Globulol; Bacchopetiolone.