Resumo

REVILLA FLORES, Efraín Moisés. REACTIVE OXYGEN SPECIES, IMPORTANCE AND PATHOLOGICAL IMPLICATIONS. Rev Cient Cienc Méd [online]. 2021, vol.24, n.2, pp.125-132.  Epub 31-Dez-2021. ISSN 1817-7433.  https://doi.org/10.51581/rccm.v24i2.401.

Oxygen, an essential molecule for aerobic organisms, is widely studied for its role in the physiology and pathophysiology of different diseases, constituting a fundamental part of medical knowledge. Describe the role of reactive oxygen species, its importance, regulation and consequences in the body. Information was obtained through the databases of Google academics, Frontiers, Research gate, Karger, ScienceDirect, PubMed, including those with level II scientific evidence, which compare the functionality in a pathological environment of reactive species and the organic response in the human organism. Reactive oxygen species are products of the daily metabolism of our body, have an important role in many physiological processes necessary for the survival of cells, can also be stimulated its production in pathological states where the capacity of the body and its antioxidant systems must maintain a balance to avoid further damage by excess of these reactive species, which can unleash more damage even ranging from macromolecules and even reaching the genetic level. From different cellular levels, a loss of balance can be triggered by oxidative stress, which is part of the molecular basis for the onset of different complications. The inclusion of exogenous antioxidants could ensure the maintenance of the balance ERO / antioxidant. The balance given by different cellular mechanisms before the oxidative stress, could be lost causing an irreversible damage, so our vision about the damage caused by different pathological entities must be extended to a more molecular point, helping in its outcome and preventing complications.

Palavras-chave : Oxygen; reactive oxygen species; oxidative stress.

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