Resumo

QUIROGA SELEZ, Gabriela et al. Chemical study of seedlings of Galipea Longiflora (Evanta); A bio-guided approach. Rev. Bol. Quim [online]. 2016, vol.33, n.4, pp.134-141. ISSN 0250-5460.

Abstract The active principies (quinolinic alkaloids) from Galipea longiñora (Evanta) were isolated and characterized . These alkaloids showed low toxicity and a good in vitro activity against Leishmania strains. Seedlings of different ages of this medicinal species were developed. The work has been focused on the analysis of variations of quinolinic alkaloids present in extracts of the seedlings and the variation of the antiparasitic activity compared with each other and with the total alkaloids in adult specimens. Five common major quinolinic alkaloids were identified in the adult-age tree and in the seedlings. Fourteen alkaloids were identified in the seedlings, compounds such as Shikimina, and 2-(3`,4`-metoxiphenylquinoline) appear when the seedlings get older. As a rule the PAT shows better biological activity than CAT with an IC50 of 13,41,2g/mL on L. amazonensis and 7,20.55g/mL on L. braziliensis . This comparison between the variation of the antiparasitic activity against the variation of seedling size and chemical composition of PAT give us a pattern of which molecules will have influence in the biological activity.

Palavras-chave : seedlings; quinoline alkaloids; leishmanicidal activity; PAT.

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