Abstract

NAVIA B., Ma. del Pilar et al. VALUES OF THE I/T RATIO OF IMMATURE TO TOTAL NEUTROPHILS IN NEONATAL SEPSIS. Cuad. - Hosp. Clín. [online]. 2005, vol.50, n.1, pp.17-24. ISSN 1562-6776.

RESEARCH QUESTION Which are the sensitivity, specificity and predictive values of the I/ T ratio of immature to total neutrophils in neonatal Sepsis of preterm, term or post term newbornsg? OBJECTIVE To determine the sensitivity, specificity and predictive values of the I/T ratio of immature to total neutrophils in neonatal sepsis. DESIGN Diagnostic test PARTICIPANTS 268 preterm, term and post term neonates attended in the Neonatal Service of the Hospital de la Mujer with the clinical diagnosis of neonatal sepsis during the year 2002-04. PLACE INLASA, Genetic Institute and IINSAD - UMSA METHODS We collected blood samples for cultures and for I/T relationship, we follow the protocol of the National Committee for Clinical Laboratory Standards on Cellular Morphology. Clinical informationwere collected from each neonate including birth weight, sex, gestational age, maternal complications, intrapartum complications and apgar scores. RESULTS The sensitivity obtainedf with the new test, the gold Standard, blood cultures and clinical signs was 55 and 63% respectively. The especificity was 64 and 70%. The positive predictive value was 36 and 63% and the negative was 79 and 71 %. So, the I/T index is more specific when it is related to the clinical signs. CONCLUSIONS The sensitivity, specificity and predictive values of the I/T test helps in the diagnosis of neonatal sepsis; it is a low cost rapid test.

Keywords : Sepsis; Newborn; I/T ratio.

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