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Gaceta Médica Boliviana
Print version ISSN 1012-2966On-line version ISSN 2227-3662
Abstract
VARGAS-DIAZ, Esperanza Gissela; ALBINO-CORNEJO, Graciela and QUIROZ-RUIZ, Hans Ramón. CD4 lymphocyte count, viral load and oral Candida colonization in people living with HIV/AIDS. Gac Med Bol [online]. 2023, vol.46, n.1, pp.18-22. Epub June 01, 2023. ISSN 1012-2966. https://doi.org/10.47993/gmb.v46i1.623.
Objectives:
to determine the correlation between CD4 count, viral load, and oral Candida colonization in people living with HIV/AIDS (PLWHA) receiving antiretroviral therapy (ART).
Methods:
a correlational cross-sectional study was conducted with 35 participants receiving antiretroviral treatment. Using flow cytometry, the CD4 count was determined; the viral load was determined by RT-PCRq and confirmation of oral colonization was made by isolating Candida spp.
Results:
CD4 count was significantly inversely correlated with viral load (Spearman's rho = -0.457, p=0.006; Kendall Tau-b= -0.306, p=0.012) and with oral Candida colonization (Spearman's rho = -0.442, p=0.008; Kendall Tau-b= -0.366, p=0,010), no statistical significance was found between viral load and colonization (p>0.05).
Conclusions:
in PLWHA receiving ART, low CD4 counts are associated with greater oral colonization by Candida; no association of said colonization with viral load was found.
Keywords : HIV; CD4 lymphocyte Count; viral load; oral candidiasis.