Revista Boliviana de Química

Evaluación de la calidad de jarabe de glucosa producido por hidrólisis enzimatica a partir de almidón de yuca (Manihot esculenta)

Quality assessment of glucose syrup produced during enzymatic hydrolysis of alpha-amylase and amyloglucosidase Dextrozyme BAN 480L 1.5x DX by three methods: polarimetric, spectrophotometric and Nuclear Magnetic Resonance from cassava (Manihot esculenta).

Evaluación de calidad de jarabe de glucosa, producido durante la hidrólisis enzimática de alfa-amilasa BAN 480L y amiloglucosidasa Dextrozyme DX 1.5x, por tres métodos: polarimétrico, espectrofometrico y de Resonancia Magnética Nuclear, a partir de yuca (Manihot esculenta)

Comportamiento electroquímico de la droga anticancer carboplatin y sus interacciones con las bases nitrogenadas sobre el electrodo de oro en condiciones fisiológicas.

The electrochemical behavior results of anticancer Carboplatin (CBDCA) and interactions with adenine, guanine, cytosine and thymine (BASES), allowed knowing the formation of strong bonds between CBDCA, adenine and guanine. These bonds stop DNA replication in cancer cells. The study was carried out by cyclic voltammetry BAS 50W model on a gold electrode at pH = 7,4 and Proton Nuclear Magnetic Resonance ¹H-NMR. The Free CBDCA voltammogram showed an oxidation signal on + 685,5 mV and CBDCA-BASES adducts showed a displacement and disappearance of the CBDCA oxidation signal.

Los resultados del comportamiento electroquímico del anticáncer carboplatino (CBDCA) e interacciones con adenina, guanina, citosina y timina (BASES), permitieron conocer la formación de enlaces fuertes entre CBDCA, adenina y guanina. Estos enlaces detienen la replicación del DNA en células cancerosas. El estudio se llevó a cabo con voltametría cíclica modelo BAS 50W sobre el electrodo de oro a un pH=7,4 y Resonancia Magnética Nuclear de Protón,1H-NMR. El voltamograma de CBDCA libre mostró una señal de oxidación en + 685,5 mV y los aductos CBDCA-BASES mostraron desplazamiento y desaparición de la señal de oxidación del CBDCA.

Síntesis de alquenos por reacciones de fragmentación; vistas mecanísticas; De la serie: El cuaderno de notas de química orgánica, un enfoque didáctico, N"5.

This is the fifth chapter in the series published by the same authors: "The Organic Chemistry Notebook Series, a Didactical Approach". Here we offer the mechanistic views of the synthesis of alkenes by fragmentation reactions. The aim of this series of studies is to help students to have a graphical view of organic synthesis reactions of diverse nature. Fragmentation reactions can conduct to the synthesis of alkenes. This is not a common method, but useful under determined conditions. For example, the fragmentation of monotoluene-p-sulphonates or methanesulphonates of suitable cyclic 1,3-diols is reviewed and the corresponding mechanism proposed. The preparation of E-cyclodecenone and cyclodecadienes by fragmentation of substituted decalylboranes is also described mechanistically. The description of the fragmentation of bicyclic compounds to afford alkenes like macrolides from acetaltosylate is also included here. The preparation of acyclic alkenes from cyclic precursors is also mechanistically described here. We have used a series of reactions reviewed by W. Carruthers, and we have proposed didactical and mechanistic views for them. This latest approach is included in the synthetic methods reviewed by W. Carruthers with respect to the "Formation of carbon-carbon double bonds".